Volume 3, Number 2 (OCCUPATIONAL MEDICINE JOURNAL 2011)                   tkj 2011, 3(2): 11-15 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Sadeghniiat Haghighi K, Noori E, Hassanzadeh G, Dehpour A. Gastric mucosal damage due to partial sleep deprivation in rats. tkj. 2011; 3 (2) :11-15
URL: http://tkj.ssu.ac.ir/article-1-40-en.html

MD Tehran University of Medical Sciences , sadeghniiat@yahoo.com
Abstract:   (7604 Views)
Abstract Background: Nowadays, working long hours and shift work are inevitable, even though these working schedules are associated with several physical and mental effects. Gastrointestinal complaints are common among their physical effects. Recent studies have shown organoprotective effect of melatonin in gastrointestinal tract. In this study we investigated gastric mucosal damage due to partial sleep deprivation and the possible role of melatonin in this damage. Methods: 24 male rats were assigned in two groups: 12 rats in control group with normal sleep and 12 rats in partial sleep deprivation group. For partial sleep deprivation, we used a slowly rotating cylindrical cage, which was rotating 23 hours a day for 14 days. Animals were food deprived in the last 24 hours of study. Finally, their stomachs were assessed grossly and histologically. We also performed ELISA assay for measurement of their serum melatonin. Results: Mucosal damage was seen to some extent in both groups. Damage severity was significantly higher in partial sleep deprivation group (P<0.001). In addition, serum melatonin was significantly lower in partial sleep deprivation group (P<0.001). Conclusion: We conclude that partial sleep deprivation could induce gastric mucosal damage in rats. Even though serum melatonin was lower in partial sleep deprived rats. So we could propose that decreased serum melatonin might have a role in this damage.
Full-Text [PDF 306 kb]   (799 Downloads)    
Type of Study: Research |
Received: 2012/02/18

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author

© 2015 All Rights Reserved | Occupational Medicine Quarterly Journal

Designed & Developed by : Yektaweb